Skin Care GuideThe Ultimate Guide to Skin Care

While it is impossible to avoid wrinkles altogether your whole life the natural way, it is possible to stay wrinkle-free for a longer time. These are some simple steps that will help you delay signs of aging:

BOILS

Life sciences product developer Senetek says it has initiated trials that will determine the efficacy of its Pyratine 6 compound on acne Rosacea, having evaluated positive results through separate trials comparing it to Kinetin, the company’s original anti-aging active ingredient.

Senetek says it has carried out an independent analysis that evaluated the effectiveness of its second generation cytokinin, Pyratine 6, against the original anti-aging ingredient, comparing results of separate clinical studies.

The results of the analysis showed that the subjects in the Pyratine 6 clinical trial demonstrated that, compared to Kinetin, it was significantly more effective as an anti-aging ingredient.

Subjects in the trial reported that over an eight week period the appearance of wrinkles improved by 22 per cent with Pyratine 6, whereas only a 2 per cent improvement was reported for Kinetin.

Likewise, over the same period, skin roughness improved by 86 per cent with Pyratine 6, compared to only 35 per cent for Kinetin, and overall aging improved by 24 per cent with Pyratine 6, compared to just 3 per cent with Kinetin.

The results of the trial led to NOVA dermal phase meter evaluations being carried out on the Pyratine 6 compound to determine the effects on reductions in skin redness and acne.

These tests showed improvements in skin moisture of 35 per cent over eight weeks and 41 per cent over 12 weeks, while redness was reduced by 42 per cent over eight weeks and 62 per cent over 12 weeks.

Likewise the compound was said to be well tolerated by all the subjects, producing no notable skin irritations or allergic reactions.

“The data collected through the comparative analysis of Pyratine 6 and Kinetin has given us significant reason to focus our efforts on taking the strategic steps necessary to launch Pyratine 6 commercially as an anti-aging compound as well as initiate clinical trials to prove that Pyratine 6 can also be used as an effective treatment for Acne Rosacea,” said Frank Massino, Senetek CEO.

The company says that following the results of its trials, an IRB-approved pilot clinical study has now been initiated to determine the efficacy of Pyratine 6 as a treatment for Rosacea, which will be conducted at the University of California.

The outcome of these trials has also influenced a decision by one of the company’s prospective licensees, which is a major cosmetics company, to commence separate clinical trials to determine the efficacy of Pyratine 6 for both skin whitening and acne treatments

Temporary hair removal is accomplished with conventional treatments such as shaving, waxing and epilation. Another method is the use of selective photolysis, which is light energy that is produced by the laser, and is targeted at the pigment in hair. This causes destruction of hair follicles while sparing surrounding structures (i.e., the skin).

Long lasting hair removal can be achieved with the use of several available lasers. Total temporary hair removal, which lasts for several months, can be done in almost all patients. However, total permanent laser hair removal is not commonly done. Stable permanent hair removal may be possible in some cases and usually requires multiple treatment sessions.

FAQ

1. Is laser hair removal painful?

Laser hair removal can be mild to moderately uncomfortable. Each individual hair follicle is surrounded by nerve endings. While some patients may be able to tolerate the procedure without the use of an anesthetic, others may find the application of an anesthetic cream (such as EMLA) helpful. A generous layer of anesthetic cream is applied for 30-60 minutes before the procedure and can provide adequate relief from discomfort during the procedure.

2. How many treatments are necessary?

For satisfactory, long-lasting hair removal most patients require three to six treatments. The interval between treatments varies between 4 and 12 weeks, and will depend on your hair color, the type of laser used, and the location treated.

3. What are the complications?

Fortunately, the complications of laser hair removal are rare if it’s done by an experienced and skilled physician. You should expect a certain degree of pain, swelling and redness around the hair follicle after each treatment session. These symptoms resolve over the following 24 hours and include:

- Pigment alteration: Postinflammatory hyperpigmentation or darkening of the skin next to the treated area has been reported in 5% of patients and is sometimes seen in darker skinned individuals. Strict sun avoidance is recommended. Hypopigmentation, or lightening of the surrounding skin, has also been reported. These adverse effects are usually temporary. Alteration in underlying pigments is also a risk, especially when Q-switched lasers are used.
- Infection: Bacterial Skin Infections are rare and occur when the superficial skin is injured. Antibiotic treatment may be prescribed, but generally good wound care is sufficient to prevent infection. If you have had prior episodes of cold sores or herpes simplex infections, you may develop a recurrent episode after a laser treatment. If you have a history of herpes simplex infections, your doctor should prescribe appropriate antiviral medication prior to laser hair removal to prevent a recurrent herpes episode.
- Scarring may rarely occur and generally follows an infection or superficial skin injury.

Who is a candidate for Laser Hair Removal?

Almost anybody who has undesirable hair is a candidate for laser hair removal. However certain conditions may complicate treatment. Laser hair removal achieves the best results with light-skinned, dark-haired individuals. Lasers with longer wavelengths are generally useful for darker-skinned patients.

Caution must be exercised in certain situations:

• The presence of an active bacterial or viral infection prevents treatment until the condition resolves.
• A history of hypertrophic scarring or keloid formation requires less aggressive laser treatments in order to avoid any complications.
• The presence of a suntan makes laser hair removal less effective and increases the likelihood of scarring or skin injury.
• If you have psoriasis or vitiligo, you should be warned about the possibility of causing more lesions in the treated areas.
• Most dermatologists recommend waiting 1 year after taking isotretinoin (Accutane®) before doing laser hair removal because of atypical scarring that has been associated with use of this drug during treatment.

Where?

Laser hair removal can be performed on virtually any hair bearing part of your body including your arms, legs, bikini area, back, etc.

Objectives of Therapy

1. The primary objective is safe and effective hair removal.
2. Total permanent hair removal, while desirable, is not always possible.
3. Total temporary hair removal lasting several months is a reasonable expectation.
4. Some permanent hair reduction in treated areas is possible, especially after multiple treatments.

Preoperative Care

1. You should strictly avoid sun tanning and artificial tanning products.
2. You should avoid waxing, plucking or electrolysis of any areas to be treated for at least 6 weeks before your laser treatment.
3. The use of shaving and depilatory creams is allowed.
4. If you have darker skin, you should consider a bleaching cream or skin lightening regimen.
5. You should shave the treatment areas within 24 hours prior to treatment.
6. Anesthetic cream can be applied 30-60 minutes prior to treatment
7. You should remove cosmetics prior to treatment.

Postoperative Changes

1. You will see redness and swelling around the treated hair follicles immediately following treatment.
2. Blisters and crusting are rare, though more commonly seen in darker skinned individuals.
3. Several days after treatment, hair may be extruded from the follicle.

Postoperative Care

1. Immediately following treatment, cold compresses can be applied to the skin surface
2. Emollients and/or topical corticosteroid creams can be used to keep areas moist and reduce redness and swelling.
3. Blisters and crusting are treated with antibiotic ointment and daily soaks.
4. You should strictly avoid the sun in order to prevent pigmentary changes.

Lasers used for Hair Removal

Laser energy, through the principle of selective photothermolysis (a process that involves selective absorption of an intense light pulse at wavelengths that are absorbed by the hair follicles, but not by the surrounding tissue), targets the pigment in the hair follicle. This causes destruction of hair follicles while sparing surrounding structures (i.e., the skin). Growing hair is more sensitive to destruction than resting hairs. Many of the lasers listed below utilize epidermal or skin cooling techniques. The effect of cooling the surface of the skin serves to minimize discomfort during treatment while increasing the effectiveness of the laser treatments.

1. Ruby Laser (694 nm, normal mode)
- All patients will see a growth delay of their hair. Some patients will see a permanent reduction in hair growth.
- This laser is more effective for dark hair. Blonde and gray hairs are more resistant.
- White hairs do not respond to treatment
- Epilaser® (Palomar) and Epitouch® (Sharplan) are examples of ruby lasers

2. Alexandrite Laser (755 nm, normal mode)
- All patients will see a growth delay of their hair. Some will see a permanent reduction in hair growth.
- It is effective for dark hair. Blonde and gray hairs are more resistant.
- White hairs do not respond to treatment
- It is potentially safer for darker skin than the ruby laser
- Rapid repetition rates of the laser will reduce treatment time
- Apogee® (Cynosure) uses a cooling gel on the skin
- Gentlase® (Candela) uses dynamic cooling spray